Castlevania: Harmony of Dissonance is chronologically set 50 years after Castlevania II: Simon's Quest and 44 years before Castlevania: Rondo of Blood.
Two years prior to the game's beginning, Maxim Kischine left on a training expedition in order to cope with his self-doubt after Juste Belmont was chosen over him to receive the legendary whip of the Belmont Clan, the Vampire Killer. Two years later, Maxim returned from his training expedition, badly wounded and with startling news: a childhood friend of Juste and Maxim by the name of Lydie Erlanger had been kidnapped. Maxim had also lost a great deal of his memory of the events of the past 2 years. Even so, he was able to lead Juste to the site of the disappearance, where they encountered a castle that hadn't been there previously. Juste hurried into the castle as Maxim recuperated in the entry way, promising to join Juste later.